Fri Oct 28 2022

34 articles - From Friday Oct 21 2022 to Friday Oct 28 2022

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Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews


Original articles

RCT, clinical trials, retrospective studies, etc…

Ann Intern Med

Environmental Health: A Position Paper From the American College of Physicians.

In this position paper, the American College of Physicians (ACP) seeks to inform physicians about environmental health and offers policymakers recommendations to reduce the adverse health consequences of climate change, improve air and water quality, reduce exposure to toxic substances, and address environmental injustice. ACP affirms that al communities, including people of color, people with low income, and marginalized populations, deserve to live in a healthy environment.

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Vitamin D Deficiency Increases Mortality Risk in the UK Biobank : A Nonlinear Mendelian Randomization Study.

Our study supports a causal relationship between vitamin D deficiency and mortality. Additional research needs to identify strategies that meet the National Academy of Medicine's guideline of greater than 50 nmol/L and that reduce the premature risk for death associated with low vitamin D levels. Primary funding source National Health and Medical Research Council.

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Lancet

Monofilament suture versus braided suture thread to improve pregnancy outcomes after vaginal cervical cerclage (C-STICH): a pragmatic randomised, controlled, phase 3, superiority trial.

Clinicians should use the results of this trial to facilitate discussions around the choice of suture thread to optimise outcomes. Funding National Institute of Health Research Health Technology Assessment Programme.

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N Engl J Med

Early Active Mobilization during Mechanical Ventilation in the ICU.

Among adults undergoing mechanical ventilation in the ICU, an increase in early active mobilization did not result in a significantly greater number of days that patients were alive and out of the hospital than did the usual level of mobilization in the ICU. The intervention was associated with increased adverse events. (Funded by the National Health and Medical Research Council of Australia and the Health Research Council of New Zealand; TEAM ClinicalTrials.gov number, NCT03133377.).

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Haloperidol for the Treatment of Delirium in ICU Patients.

Among patients in the ICU with delirium, treatment with haloperidol did not lead to a significantly greater number of days alive and out of the hospital at 90 days than placebo. (Funded by Innovation Fund Denmark and others; AID-ICU ClinicalTrials.gov number, NCT03392376; EudraCT number, 2017-003829-15.).

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Oxygen-Saturation Targets for Critically Ill Adults Receiving Mechanical Ventilation.

(Supported by the National Heart, Lung, and Blood Institute and others; PILOT ClinicalTrials. gov number, NCT03537937.).

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Protection against Omicron from Vaccination and Previous Infection in a Prison System.

Our findings in two high-risk populations suggest that mRNA vaccination and previous infection were effective against omicron infection, with lower estimates among those infected before the period of delta predominance. Three vaccine doses offered significantly more protection than two doses, including among previously infected persons.

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Spontaneous-Breathing Trials with Pressure-Support Ventilation or a T-Piece.

Among patients who had a high risk of extubation failure, spontaneous-breathing trials performed with PSV did not result in significantly more ventilator-free days at day 28 than spontaneous-breathing trials performed with a T-piece. (Supported by the French Ministry of Health; TIP-EX ClinicalTrials.gov number, NCT04227639.).

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Ann Intern Med

Health Care and Climate Change: Challenges and Pathways to Sustainable Health Care.

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Lancet

Haemolytic uraemic syndrome.

Unfortunately, the high cost of anti-complement therapies al but precludes their use in low-income countries. For many other forms of HUS, targeted therapies are yet to be identified.

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Offline: Sustainable development is broken and needs repair.

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N Engl J Med

Early Mobilization of Critical Care Patients - Still More to Learn.

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Improved Protocols for Ventilator Liberation.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Ann Intern Med

Annals Graphic Medicine - Dr. Mom: The Thrill of Working in the Hospital Where I Was Born.

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Environmental Health: Translating Policy Into Action.

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Safety and Immunogenicity of Intradermal Fractional Dose Administration of the mRNA-1273 Vaccine: A Proof-of-Concept Study.

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Lancet

ACT-A: "The international architecture did not work for us".

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COP27 Climate Change Conference: urgent action needed for Africa and the world.

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Cough syrup deaths expose lax drug regulation in India.

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Early warning systems for disasters key for health.

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Empty cradles: medical authority and disappeared children.

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LGBTQIA+ menopause: room for improvement.

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Searching for a cause of a gastric ulcer in case of common variable immunodeficiency: cytomegalovirus.

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Suture choice for cervical cerclage.

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N Engl J Med

Medical Malpractice Law - Doctrine and Dynamics.

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Medicare's National Coverage Determination for Aducanumab - A One-Off or a Pragmatic Path Forward?

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Spontaneous Hyphema.

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What Covid Has Taught the World about Ethics.

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Letters&Replies

Letters to the editors and authors’ replies

Lancet

Maintaining contact with clinical colleagues in Myanmar.

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The North American opioid crisis: a European perspective.

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The North American opioid crisis: draw on the expertise of people who use drugs.

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The North American opioid crisis: educational failures and incautious stoppage.

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The North American opioid crisis: evidence and nuance on prescribed safer supply.

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The North American opioid crisis: how effective are supervised consumption sites?

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